Clomiphene citrate is primarily known as a treatment for female infertility, but it can also be used to address male infertility. In men, the medication signals the brain to produce hormones that stimulate both sperm and testosterone production. For men with low testosterone who want to start a family, clomiphene citrate can help manage symptoms while preserving fertility.

Clomiphene citrate works by functioning as a selective estrogen receptor modulator (SERM). It acts on certain estrogen receptors in the body in a way that tells the brain to produce more luteinizing hormone (LH) and follicle-stimulating hormone (FSH), which in turn tell the testes to produce more testosterone and sperm.

Taking clomiphene citrate helps restore the levels of this hormone in the blood, reversing the symptoms of low testosterone that are low libido, erectile dysfunction, mood changes, loss in mental acuity, weight gain, hot flashes, and sleep disturbances. People who take it may notice improvements in alertness, sexual function, energy, mood, and overall well-being. You may not notice improvements in symptoms of low testosterone over the course of one to six months. To get the full benefits, clomiphene citrate must be taken regularly for three months.